Effects of intracerebroventricular injection of histamine and H1, H2 receptor antagonists on electrocardiographic parameters in broiler chickens

Authors

  • H. Nayebzadeh Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran
  • M. Rafiei Graduated from Faculty of Agriculture, Islamic Azad University, Saveh Branch, Saveh, Iran
  • M. Taati Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran
  • M. Zendehdel Department of Physiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • S. Alavi Department of Heart Diseases, Tamin Ejtemaei Hospital, Khorramabad, Iran
Abstract:

The aim of this study was to assess the effects of exogenous histamine and H1 and H2 central receptorson electrocardiographic (ECG) parameters, heart rate and mean electrical axis in broiler chickens. For thispurpose, Ross broiler chickens (750-800 g weight) received intracerebroventricularly (ICV) histamine.Moreover, to determine the receptors involved in histamine-induced alterations in ECG changes, H1 and H2blockers were administered to histamine-treated chickens. All ECGs were standardized at 1 mV = 20 mm,with paper speed of 50 mm/sec. Leads І, ІІ, ІІІ, aVR, aVL and aVF were recorded. Injection of histamine(200 and 300 μg) decreased the duration of T wave and QRS complex and elevated the heart rate ascompared to the control group (P

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Journal title

volume 12  issue 3

pages  192- 198

publication date 2011-09-20

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